Introduction and General Information

A FRAC OSBPI task force was formed in 2015 to generate common resistance management recommendations for the fungicide oxathiapiprolin and other OSBP-inhibitors.

Oxathiapiprolin is a fungicide active against oomycete fungi and used for the control of Phytophthora and downy mildews of numerous crops.

Oxathiapiprolin inhibits the oxysterol binding protein (OSBP), which is implicated in the movement of lipids between membranes, among other processes. Inhibiting OSBP may disrupt other processes in the fungal cell, such as signalling, maintaining cell membranes, and the formation of more complex lipids that are essential for the cell to survive.

Oxathiapiprolin has been classified under the FRAC Code U15. The resistance risk is medium to high.

FRAC Code Target site and code Group name Chemical group Common name Comments
U15 oxysterol binding protein (OSBP) inhibition (proposed) piperidinyl-thiazole-isoxazolines piperidinyl-thiazole-isoxazolines oxathiapiprolin Resistance risk assumed to be medium to high (single site inhibitor). Resistance management required.



Jean-Luc Genet

ERDC Dupont de Nemours France SAS
24 Rue du Moulin
68740 Nambsheim, France

E-Mail: Jean-Luc Genet