CAA Fungicides
Membership

The Working Group is comprised of the following members:

Michael Merk (chairman) BASF, Milan, Italy
Randall Gold BASF, Limburgerhof, Germany
Gerd Stammler BASF, Limburgerhof, Germany
Albert Schirring Bayer CropScience, Monheim, Germany
Marie-Pascale Latorse Bayer CropScience, Lyon, France
Masaru Yokoyama KI-Chemical, Brussels, Belgium
Masaru Shibata KI-Chemical, Brussels, Belgium
Ulrich Gisi Syngenta, Basel, Switzerland
Bruno Decaudin Syngenta, Basel, Switzerland
Fritz Huggenberger Syngenta, Basel, Switzerland


2008 Minutes of the 2008 annual meeting(pdf)
2007 Minutes of the 2007 annual meeting(pdf)
2006 Minutes of the 2006 annual meeting(pdf)

 
1. Introduction

 
The FRAC CAA Working Group was set up in 2005 in order to generate common resistance management recommendations for the Oomycete fungicides dimethomorph, flumorph, iprovalicarb, benthiavalicarb and mandipropamid.

Concurrently the above-mentioned fungicides have been re-grouped under the new FRAC Code No. 40 in the revised FRAC Code List.

CODE TARGET SITE OF ACTION GROUP NAME CHEMICAL GROUP COMMON NAME COMMENTS
40 phospholipid biosynthesis and cell wall deposition (proposed) CAA -fungicides (Carboxylic acid amides) cinnamic acid amides

dimethomorph
flumorph

Low to medium risk. Resistance management required.
valinamide carbamates

benthiavalicarb
iprovalicarb

mandelic acid amides mandipropamid

As shown in the table, the group name Carboxylic Acid Amides ( CAA ) has been chosen. This name best represents compounds from three different chemical groups.

The mode of action of CAA compounds has not yet been fully elucidated. There are proposals for inhibition of phospholipids biosynthesis and for interference with cell wall deposition.

Sensitivity monitoring studies over several years revealed that in the populations of the late blight pathogen, Phytophthora infestans, all isolates were fully sensitive to CAA fungicides. However, in the populations of the grape downy mildew pathogen, Plasmopara viticola, isolates can be found in certain regions, which are simultaneously resistant to all CAA fungicides. Therefore, in the case of Plasmopara viticola, a positive cross resistance among all CAA fungicides is obvious for the vast majority of isolates. The degree of sensitivity covers a wide range of EC50 values with isolates being sensitive, moderately resistant and fully resistant.

Inheritance studies (Gisi et al., Plant Pathology, 2007, 56, 199-208 ) showed that sexual crosses between sensitive and CAA resistant isolates of Plasmopara viticola lead to a co-segregation of resistance to dimethomorph, iprovalicarb, benthiavalicarb and mandipropamid, but not to the phenylamide mefenoxam which was tested in parallel as an independent marker.

Further, the inheritance studies showed that the gene(s) for resistance to CAA fungicides are inherited in a recessive manner. Therefore, the entire F1 generation of crosses between sensitive and CAA resistant isolates was sensitive, and only in the F2 progeny did CAA resistance reappear in a few isolates. These results suggest that the resistance risk can be classified as moderate (as compared to high for phenylamide and QoI fungicides) and that it can be managed by appropriate product use strategies (see below).

Overall, these results explain some characteristics of CAA resistance, especially the limited spread and propagation of resistant isolates in field populations.
 

2. Resistance Monitoring 2007


2.1. Plasmopara viticola – Grape downy mildew

Disease incidence

In 2007, disease pressure was moderate to high (even severe) in the main grape growing areas of Europe. Disease management was challenging in many situations due to high disease pressure.

Field performance

Field performance of registered products was good in 2007. No resistance-related complaints have been received.

Monitoring results
(results generated by BASF, Bayer, KI-Chemical, Syngenta)

France
As in the years before, CAA resistant isolates have been detected consistently in all areas.
Some increase of the resistant isolates was observed in Burgundy, Cognac and Champagne. A stable situation was observed in the other regions compared to 2006.

Germany
Resistant isolates have been detected in all major vine-growing regions similar to 2006. The highest level was observed in Mosel area, moderate level was observed in Rheinhessen, Pfalz, Franken, Württemberg and very low level in Baden.

Italy
As in 2006 no resistance was detected except in South Tyrol and Trentino where for the first time resistance isolates were detected on a very low level.

Spain
As in 2006 no resistance was detected except in Galicia where resistant isolates were detected on a low level.

Portugal, Switzerland, Austria
As in 2006 resistant isolates were detected at a very low level.

Greece
No resistant isolates were detected.

China
No resistant isolates were detected.

2.2. Phytophthora infestans – Late blight of potatoes and tomatoes

Disease Incidence

Disease onset was rather early in the main growing potato areas and remained high.

Field performance

Field performance of CAA fungicides against late blight was good and fulfilled grower expectations. No resistance-related complaints have been received for the registered compounds.

Monitoring results
(results generated by BASF and Syngenta)

Sensitivity monitoring programs in 2007 did not detect less sensitive strains of Phytophthora infestans in Europe. These studies document that populations of P. infestans are fully sensitive to CAA fungicides and confirm the observations of previous years.

2.3. Pseudoperonspora cubensis – Downy mildew of cucurbits

In a few sites it was possible to detect resistant isolates of Pseudoperonospora cubensis. There are no complaints on the performance of CAA products from commercial fields.


3. Use Recommendations


3.1. Plasmopara viticola – Grape downy mildew

Plasmopara viticola is regarded as a high risk pathogen as classified by FRAC. Long-term experience with CAA fungicides demonstrates that the resistance risk of Plasmopara viticola to this fungicide group is moderate and can be managed through appropriate use strategies. This experience has been confirmed again in 2007 season and is supported by the fact

  • that resistance related complaints never became known with CAA fungicides as long as mixtures with multi-site fungicides have been used
  • that the resistance frequency in the affected regions is mostly fluctuating with no clear progression over years and regions
  • that resistance genes are inherited in a recessive manner

Use Recommendations:

  • Apply a maximum of 4 CAA sprays during one crop cycle
  • Apply CAA fungicides always in mixture with effective partners such as multi-sites or other non cross resistant fungicides
  • An effective partner for a CAA fungicide is one that provides satisfactory disease control when used alone at the mixture rate

3.2. Phytophthora infestans – Late blight of potato and tomato

No resistant isolates from field populations have been found since the introduction of CAA fungicides over 10 years ago.

Phytophthora infestans is regarded as a medium risk pathogen as classified by FRAC. Long-term experience with CAA fungicides demonstrates that the resistance risk of Phytophthora infestans to this fungicide group is low to moderate. For effective resistance management a precautionary strategy has to be implemented:

  • Maximum 50 % of the total number of intended applications for Phytophthora-control
  • Alternation with other modes of action is recommended

For more detailed product recommendations refer to the use guidelines published by the respective CAA manufacturers.

3.3. Pseudoperonospora cubensis – Downy mildew of cucurbits

Pseudoperonospora cubensis is regarded as a high risk pathogen as classified by FRAC.

Use recommendation:

For product recommendations refer to the use guidelines published by the respective CAA manufacturers.

3.4. Other Oomycete (Peronosporomycete) Pathogens

Some of the downy mildew pathogens are regarded as moderate risk pathogens (e.g. Bremia lactucae) as classified by FRAC. In spite of the use of CAA fungicides for more than 10 years against a range of such Oomycete pathogens, no reports on the occurrence of less sensitive field populations are available.

For effective resistance management a precautionary strategy has to be implemented:

  • Maximum 50 % of the total number of intended applications for disease control
  • Alternation with other modes of action is recommended

For more detailed product recommendations refer to the use guidelines published by the respective CAA manufacturers.

Source: www.frac.info
March 2008



 
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Contact



Dr. Michael Merk

Chairman

BASF Italia Srl
Cesano Maderno (Milan)
Italy
Tel. +39 0362 512-415 FAX: +39 0362 512-640 Email: michael.merk@basf.com

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